Zhongke Guorui provides safe pharmacological testing services in large and small animals to explore the effects of drugs on the central nervous system, respiratory system and cardiovascular system, etc., to support drug development.

Safety pharmacology mainly studies the adverse effects of drugs on the central nervous system, cardiovascular system and respiratory system when the drug is in the therapeutic range or above the therapeutic range. Additional and/or complementary safety pharmacological studies, which may be conducted as needed, should also include observations of the urinary system, autonomic nervous system, digestive system and other organ tissues. The purpose and significance of safety pharmacology research is to discover unexpected pharmacological effects that may be related to clinical safety, evaluate adverse reactions or pathological effects observed in toxicological tests or clinical studies, and explore the mechanism of adverse reactions.

Core combination test: spontaneous activity, functional observation combination (FOB), whole body plethysmography, telemetry

hERG experiment