Ophthalmic toxicology

To evaluate the safety and effectiveness of ophthalmic drugs, and to evaluate the effects of drugs on the eye after systemic administration. He is good at various intraocular drug administration in different species of animals, and has established experimental animal models of corneal neovascularization, corneal epithelial injury and cataract. With advanced eye examination instruments, such as slit-lamp, tachymeter, fundus camera, OCT, electroretinogram, and ophthalmic operating microscope, it can perform complete live animal eye examination and provide support for preclinical research of ophthalmic drugs.

Category: Non-clinical safety evaluation

Medicines for human purposes

I. Introduction

To evaluate the safety and effectiveness of ophthalmic drugs, and to evaluate the effects of drugs on the eye after systemic administration. He is good at various intraocular drug administration in different species of animals, and has established experimental animal models of corneal neovascularization, corneal epithelial injury and cataract. With advanced eye examination instruments, such as slit-lamp, tachymeter, fundus camera, OCT, electroretinogram, and ophthalmic operating microscope, it can perform complete live animal eye examination and provide support for preclinical research of ophthalmic drugs.

Ii. Main research content

1. Non-clinical studies of ophthalmic drugs:

Safety evaluation, pharmacodynamic evaluation, pharmacokinetics/toxokinetics (eye circulation)

2. Animal species:

Rodents (large, mouse), rabbits, dogs, non-human primates

3. Method of administration:

Topical ophthalmic use: intraconjunctival capsule administration

Intraocular injection: anterior chamber injection, vitreous cavity injection, subconjunctival injection, retrobulbar injection

Systemic administration: intravenous, oral, intramuscular, subcutaneous

4. Eye disease model:

Clinical disease

Molding method

Animal germline

Corneal neovascularization

Corneal suture induction

New Zealand white rabbit

Alkali burn induction

Corneal epithelial injury

Corneal epithelial cell curettage induction

New Zealand white rabbit

cataract

Induction by subcutaneous injection of sodium selenite

SD rat

Retinal melanosis

Retigabine induction

Long Evans rat

5. Live eye examination:

Slit-lamp examination and corneal fluorescein sodium staining examination

Direct/indirect ophthalmoscopy

Fundus photography FP

Fundus fluorescence imaging FFA

Optical coherence tomography OCT

Infrared reflection imaging IR

Fundus autofluorescence scanning BAF

Intraocular pressure IOP

Electroretinogram ERG

Visual evoked potential (VEP)