Safety pharmacology

The purpose of safety pharmacological research is to find unexpected pharmacological effects that may be related to clinical safety, evaluate adverse pharmacological or pathophysiological reactions observed in toxicological experiments or clinical studies, and explore the mechanism of adverse reactions. We have an experienced professional research team of safety pharmacology and advanced and complete imported test equipment, which can provide customers with a full set of safety pharmacological test services in accordance with CFDA, ICH S7A and S7B guidelines and international GLP standards.

Category: Non-clinical safety evaluation

Medicines for human purposes

The purpose of safety pharmacological research is to find unexpected pharmacological effects that may be related to clinical safety, evaluate adverse pharmacological or pathophysiological reactions observed in toxicological experiments or clinical studies, and explore the mechanism of adverse reactions. We have an experienced professional research team of safety pharmacology and advanced and complete imported test equipment, which can provide customers with a full set of safety pharmacological test services in accordance with CFDA, ICH S7A and S7B guidelines and international GLP standards.

Instrument and equipment

Multi-channel physiological data acquisition system

DSI Physiological Data Acquisition and Analysis System (Telemetry system)

Spontaneous activity video acquisition and analysis system

Whole body plethysmography system

Vest telemetry system

Animal species

Dogs/non-human primates

Mice/rats

Core combination

Cardiovascular system: awake dogs and monkeys (telemetry: ECG/blood pressure/heart rate/body temperature), anesthetized dogs and monkeys (ECG/blood pressure/heart rate/breathing)

Respiratory system (rat/mouse) : respiratory rate/tidal volume/ventilate per minute, central nervous system (rat/mouse/monkey), functional observation combination experiment, modified Irwin method

In vitro electrophysiology: potassium ion channels (hERG), sodium ion channels and calcium ion channels

Additional test

Central nervous system: behavior, learning and memory

Cardiovascular system: myocardial contractility, action potential

Respiratory system: airway resistance, etc

Supplementary experiment

Gastrointestinal system

Urinary/renal system

Neuromuscular function

Neuromuscular coordination